Reduktion der LDL-Werte schützt nicht vor Herzerkrankungen

Jahrelang wurde über “gutes” und “schlechtes” Cholesterin geredet, unzählige Artikel dazu veröffentlich und Millionen Patienten verunsichert oder mit Cholesterolsenkern (Statine behandelt. Nun scheint es Gewissheit zu geben, dass all dies unnötig gewesen ist.

In einer Metastudie wurden 35 randomisierte kontrollierte Studien zum Einfluss von LDL-Cholesterin auf das Risiko kardiovaskulärer Erkrankungen untersucht:

The widely held theory that there is a linear relationship between the degree of LDL-C reduction and the degree of cardiovascular risk reduction is undermined by the fact that some RCTs with very modest reductions of LDL-C reported cardiovascular benefits while others with much greater degrees of LDL-C reduction did not

These population studies suggest that, despite the widespread use of statins, there has been no accompanying decline in the risk of cardiovascular events or cardiovascular mortality. In fact, there is some evidence that statin usage may lead to unhealthy behaviours that may actually increase the risk of cardiovascular disease.

Hit or miss: the new cholesterol targets | BMJ Evidence-Based Medicine